| Team | Time | Athletes | Meet | Meet Date | |
|---|---|---|---|---|---|
| 1 | Seminole (Sanford) | 40.57 | Beckford, Lewis, McDonald, Turner | FHSAA Class 4A & Para Track & Field State Championships | May 14, 2022 |
| 2 | Lake Mary | 42.29 | Soto, Jones, Woodward, Ramos | FHSAA Class 4A & Para Track & Field State Championships | May 14, 2022 |
| 3 | Lake Howell | 43.23 | Cummings, Stell, Mitchell, Quaily | FHSAA 4A Region 1 | May 7, 2022 |
| 4 | Oviedo | 43.29 | Washington, Saunders, Curry, Joy | FHSAA 4A Region 1 | May 7, 2022 |
| 5 | Spruce Creek | 43.81 | Mobley, Evans, Davis, Onwunali | Deland HS Big D Relays 2022 | Mar 5, 2022 |
| 6 | Lake Brantley | 44.07 | Harris, Woodson, Williams, Davis | FHSAA 4A District 3 | Apr 22, 2022 |
| 7 | DeLand | 44.18 | Cunningham, Gilbert, Myrie, Soto, Jr. | 5-Star Conference Meet | Apr 13, 2022 |
| 8 | Hagerty | 44.31 | Miller, Farwig, Vail, Piris | FHSAA 4A District 3 | Apr 22, 2022 |
| 9 | Lyman | 45.48 | Bouey, Harris, Rodriguez, Grimes | FHSAA 4A District 3 | Apr 22, 2022 |
| 10 | University (OC) | 46.22 | Irwin, Lebron, Henry, Cook | 5-Star Conference Meet | Apr 13, 2022 |
| Team | Time | Athletes | Meet | Meet Date | |
|---|---|---|---|---|---|
| 1 | Seminole (Sanford) | 47.54 | Hemmings, Soremi, Hillery, Allen | FHSAA Class 4A & Para Track & Field State Championships | May 14, 2022 |
| 2 | Lake Mary | 49.36 | Wynn, Jiles, Reed, Iva | FHSAA 4A Region 1 | May 7, 2022 |
| 3 | Hagerty | 49.49 | Facey, Jaime, Farwig, McGrath | FHSAA 4A Region 1 | May 7, 2022 |
| 4 | Lake Howell | 49.81 | Lowe, Golson, Stokes, Watson | FHSAA 4A District 3 | Apr 22, 2022 |
| 5 | Spruce Creek | 49.96 | Gaines, Wills, Johnson, Means | 5-Star Conference Meet | Apr 13, 2022 |
| 6 | Lake Brantley | 51.01 | Ary, Berehausky, Garden, Lane | Mount Dora Christian Invitational Meet #1 | Mar 29, 2022 |
| 7 | University (OC) | 52.63 | Walton, Arroyo Canales, Stahlman, Burgos Rosado | Deltona HS Senior Night Meet | Apr 6, 2022 |
| 8 | DeLand | 52.81 | Woods, Allen, Brown, Yebba | FHSAA 4A District 3 | Apr 22, 2022 |
| 9 | Oviedo | 54.12 | Meade, Nemasango, Maiorino, Wahl | Charlie Harris Relays | Mar 11, 2022 |
| 10 | Lyman | 1:00.87 | Aquino, Loreta lozada, Cortes, Ortiz Rodriguez | Seminole Athletic Conference Championship @ Sanford Seminole | Apr 13, 2022 |
| Team | Time | Athletes | Meet | Meet Date | |
|---|---|---|---|---|---|
| 1 | Spruce Creek | 4:05.52 | Davis, Gaines, Means, Wills | FHSAA 4A District 3 | Apr 22, 2022 |
| 2 | Lake Mary | 4:11.19 | Mcclelland, Sapp, Reed, Reese | Seminole Athletic Conference Championship @ Sanford Seminole | Apr 13, 2022 |
| 3 | Oviedo | 4:13.44 | Wahl, Cabal, Meade, Adamson | FHSAA 4A District 3 | Apr 22, 2022 |
| 4 | Seminole (Sanford) | 4:14.39 | Pierce, Nock, Soremi, Rivera | Seminole Athletic Conference Championship @ Sanford Seminole | Apr 13, 2022 |
| 5 | Lake Brantley | 4:15.56 | Lane, Brooks, Simpson, Garden | FHSAA 4A Region 1 | May 7, 2022 |
| 6 | Hagerty | 4:24.06 | Jaime, Jacob, Trapaga Morejon | Seminole Athletic Conference Championship @ Sanford Seminole | Apr 13, 2022 |
| 7 | Lake Howell | 4:27.97 | Watson, Slater, Garza, Crawford | Coach Ernest McPherson Invitational @ Sanford Seminole High | Apr 8, 2022 |
| 8 | DeLand | 4:29.81 | Neira, Hancock, Bordeaux, Neira | 5-Star Conference Meet | Apr 13, 2022 |
| 9 | University (OC) | 4:36.45 | Barr-Miller, Judge, Arroyo Canales, Theodore | Deltona HS Season Opener | Feb 23, 2022 |